Regioselective multicomponent domino reactions providing rapid and efficient routes to fused acridines

Jin Peng Zhang, Wei Fan, Jie Ding, Bo Jiang, Shu Jiang Tu, Guigen Li

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Regioselective three-component reactions of aromatic aldehydes with indazol-5-amine and 2-hydroxy-1,4-naphthoquinone in HOAc under microwave irradiation have been developed. In this one-pot reaction, a series of new pyrazole-fused benzo[h]acridine derivatives with 1,2-diketone unit were synthesized with high chemical yields. The resulting pyrazole-fused acridines were employed to further react with aldehydes and ammonium acetate to give polycyclic oxazole-fused pyrazolo[3,4-j]acridines. The present green synthesis shows several advantages including operational simplicity and fast reaction rates, which makes it a useful and attractive process of library generation for drug discovery.

Original languageEnglish
Pages (from-to)1065-1077
Number of pages13
JournalHeterocycles
Volume88
Issue number2
DOIs
StatePublished - 2014

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