Regioselective Cross-Couplings of Coumarins and Flavones with Ethers via C(sp3)-H Functionalization

Ben Niu, Wannian Zhao, Yingcai Ding, Zhaogang Bian, Charles U. Pittman, Aihua Zhou, Haibo Ge

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


(Chemical Equation Presented) Coumarin and flavone derivatives are highly valuable molecules in drug discovery. Here, two new regioselective cross-dehydrogenation couplings of coumarins and flavones with different ethers via C(sp3)-H functionalization processes were developed, generating new ether-substituted derivatives not previously reported. These reactions proceeded well via radical mechanisms and provided the corresponding products in good yields.

Original languageEnglish
Pages (from-to)7251-7257
Number of pages7
JournalJournal of Organic Chemistry
Issue number14
StatePublished - Jul 17 2015


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