TY - JOUR
T1 - Recent advances of functional proteomics in gastrointestinal cancers-a path towards the identification of candidate diagnostic, prognostic, and therapeutic molecular biomarkers
AU - Abyadeh, Morteza
AU - Meyfour, Anna
AU - Gupta, Vivek
AU - Moghaddam, Masoud Zabet
AU - Fitzhenry, Matthew J.
AU - Shahbazian, Shila
AU - Salekdeh, Ghasem Hosseini
AU - Mirzaei, Mehdi
N1 - Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/11/2
Y1 - 2020/11/2
N2 - Gastrointestinal (GI) cancer remains one of the common causes of morbidity and mortality. A high number of cases are diagnosed at an advanced stage, leading to a poor survival rate. This is primarily attributed to the lack of reliable diagnostic biomarkers and limited treatment options. Therefore, more sensitive, specific biomarkers and curative treatments are desirable. Functional proteomics as a research area in the proteomic field aims to elucidate the biological function of unknown proteins and unravel the cellular mechanisms at the molecular level. Phosphoproteomic and glycoproteomic studies have emerged as two efficient functional proteomics approaches used to identify diagnostic biomarkers, therapeutic targets, the molecular basis of disease and mechanisms underlying drug resistance in GI cancers. In this review, we present an overview on how functional proteomics may contribute to the understanding of GI cancers, namely colorectal, gastric, hepatocellular carcinoma and pancreatic cancers. Moreover, we have summarized recent methodological developments in phosphoproteomics and glycoproteomics for GI cancer studies.
AB - Gastrointestinal (GI) cancer remains one of the common causes of morbidity and mortality. A high number of cases are diagnosed at an advanced stage, leading to a poor survival rate. This is primarily attributed to the lack of reliable diagnostic biomarkers and limited treatment options. Therefore, more sensitive, specific biomarkers and curative treatments are desirable. Functional proteomics as a research area in the proteomic field aims to elucidate the biological function of unknown proteins and unravel the cellular mechanisms at the molecular level. Phosphoproteomic and glycoproteomic studies have emerged as two efficient functional proteomics approaches used to identify diagnostic biomarkers, therapeutic targets, the molecular basis of disease and mechanisms underlying drug resistance in GI cancers. In this review, we present an overview on how functional proteomics may contribute to the understanding of GI cancers, namely colorectal, gastric, hepatocellular carcinoma and pancreatic cancers. Moreover, we have summarized recent methodological developments in phosphoproteomics and glycoproteomics for GI cancer studies.
KW - Colorectal cancer
KW - Gastric cancer
KW - Glycoproteomics
KW - Hepatocellular carcinoma
KW - Pancreatic cancer
KW - Phosphoproteomics
UR - http://www.scopus.com/inward/record.url?scp=85095995356&partnerID=8YFLogxK
U2 - 10.3390/ijms21228532
DO - 10.3390/ijms21228532
M3 - Review article
C2 - 33198323
AN - SCOPUS:85095995356
VL - 21
SP - 1
EP - 25
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 22
M1 - 8532
ER -