Recent Advances in First-Row-Transition-Metal-Catalyzed Dehydrogenative Coupling of C(sp3)-H Bonds

Jinmin Miao, Haibo Ge

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150 Scopus citations


Transition-metal-catalyzed cross dehydrogenative coupling is a highly efficient tool for functionalization of C(sp3)-H bonds. In particular, the inexpensive first-row transition metals have been demonstrated as effective catalysts in this process. This microreview summarizes recent progress in two classes of first-row-transition-metal-catalyzed dehydrogenative reactions: intramolecular cyclization for C-C bond formation, and directed site-selective C-H functionalization. These transformations provide concise and practical approaches for preparation of various organic compounds, but so far they are underdeveloped.

Original languageEnglish
Pages (from-to)7859-7868
Number of pages10
JournalEuropean Journal of Organic Chemistry
Issue number36
StatePublished - Dec 1 2015


  • C-C coupling
  • C-H activation
  • Dehydrogenative coupling
  • Homogeneous catalysis
  • Nitrogen heterocycles
  • Synthetic methods


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