Real-time, on-line monitoring of organic chemical reactions using extractive electrospray ionization tandem mass spectrometry

Liang Zhu, Gerardo Gamez Goytia, Huan Wen Chen, Hao Xi Huang, Konstantin Chingin, Renato Zenobi

Research output: Contribution to journalArticlepeer-review

Abstract

Extractive electrospray ionization mass spectrometry (EESI-MS) for real-time monitoring of organic chemical reactions was demonstrated for a well-established pharmaceutical process reaction and a widely used acetylation reaction in the presence of a nucleophilic catalyst, 4-dimethylaminopyridine (4-DMAP). EESI-MS provides real-time information that allows us to determine the optimum time for terminating the reaction based on the relative intensities of the precursors and products. In addition, tandem mass spectrometric (MS/MS) analysis via EESI-MS permits on-line validation of proposed reaction intermediates. The simplicity and rapid response of EESI-MS make it a valuable technique for on-line characterization and full control of chemical and pharmaceutical reactions, resulting in maximized product yield and minimized environmental costs. Copyright (c) 2008 John Wiley & Sons, Ltd.
Original languageEnglish
Pages (from-to)2993-2998
JournalRapid Communications in Mass Spectrometry
StatePublished - Oct 2008

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