Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath

Gerardo Gamez; Liang Zhu; Andreas Disko; Huanwen Chen; Vladimir Azov; Konstantin Chingin; Günter Krämer; Renato Zenobi

doi:10.1039/c1cc10343a

Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath

Gerardo Gamez, Liang Zhu, Andreas Disko, Huanwen Chen, Vladimir Azov, Konstantin Chingin, Günter Krämer, Renato Zenobi

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Extractive electrospray ionization mass spectrometry is shown to allow real-time, in vivo drug monitoring and pharmacokinetic measurement in a non-invasive, pain-free manner as demonstrated by the mass spectral measurement of a novel exhaled breath biomarker for valproic acid, a medication used to control epilepsy.

Original language	English
Pages (from-to)	4884-4886
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	17
DOIs	https://doi.org/10.1039/c1cc10343a
State	Published - May 7 2011

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title = "Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath",

abstract = "Extractive electrospray ionization mass spectrometry is shown to allow real-time, in vivo drug monitoring and pharmacokinetic measurement in a non-invasive, pain-free manner as demonstrated by the mass spectral measurement of a novel exhaled breath biomarker for valproic acid, a medication used to control epilepsy.",

author = "Gerardo Gamez and Liang Zhu and Andreas Disko and Huanwen Chen and Vladimir Azov and Konstantin Chingin and G{\"u}nter Kr{\"a}mer and Renato Zenobi",

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AU - Gamez, Gerardo

AU - Zhu, Liang

AU - Disko, Andreas

AU - Chen, Huanwen

AU - Azov, Vladimir

AU - Chingin, Konstantin

AU - Krämer, Günter

AU - Zenobi, Renato

PY - 2011/5/7

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N2 - Extractive electrospray ionization mass spectrometry is shown to allow real-time, in vivo drug monitoring and pharmacokinetic measurement in a non-invasive, pain-free manner as demonstrated by the mass spectral measurement of a novel exhaled breath biomarker for valproic acid, a medication used to control epilepsy.

AB - Extractive electrospray ionization mass spectrometry is shown to allow real-time, in vivo drug monitoring and pharmacokinetic measurement in a non-invasive, pain-free manner as demonstrated by the mass spectral measurement of a novel exhaled breath biomarker for valproic acid, a medication used to control epilepsy.

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DO - 10.1039/c1cc10343a

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SP - 4884

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JO - Chemical Communications

JF - Chemical Communications

IS - 17

ER -

Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath

Abstract

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