Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath

Gerardo Gamez, Liang Zhu, Andreas Disko, Huanwen Chen, Vladimir Azov, Konstantin Chingin, Günter Krämer, Renato Zenobi

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Extractive electrospray ionization mass spectrometry is shown to allow real-time, in vivo drug monitoring and pharmacokinetic measurement in a non-invasive, pain-free manner as demonstrated by the mass spectral measurement of a novel exhaled breath biomarker for valproic acid, a medication used to control epilepsy.

Original languageEnglish
Pages (from-to)4884-4886
Number of pages3
JournalChemical Communications
Volume47
Issue number17
DOIs
StatePublished - May 7 2011

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