Rare trisubstituted sesquiterpenes daucanes from the wild Daucus carota

Ahmed A. Ahmed, Mohktar M. Bishr, Mohamed A. El-Shanawany, Eman Z. Attia, Samir A. Ross, Paul W. Paré

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Phytochemical and biological investigation of the roots of the wild Daucus carota ssp. carota afforded three new and four known compounds, including four sesquiterpenes daucane esters (1-3 [new], and 4), one polyacetylene (5), one sesquiterpene coumarin (6), and sitosterol glucoside. The structures of the new compounds were determined by comprehensive NMR studies, including DEPT, COSY, NOESY, HMQC and HMBC analyses. Based on an agar diffusion assay, 1, 2 and 4-6 were screened and found to contain a range of low antibacterial activities against four gram positive (Staphylococcus aureus, Streptomyces scabies, Bacillus subtilus, Bacillus cereus) and two gram negative species (Pseudomonas aeruginosa, Escherichia coli) as well as antifungal against Fusarium oxysporum and Aspergillus niger using cup agar diffusion assay.

Original languageEnglish
Pages (from-to)1680-1684
Number of pages5
JournalPhytochemistry
Volume66
Issue number14
DOIs
StatePublished - Jul 2005

Keywords

  • Antibacterial
  • Apiaceae
  • Daucane sesquiterpenes
  • Daucus carota ssp. carota
  • Polyacetylene
  • Sesquiterpene coumarin

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