TY - JOUR
T1 - Rare trisubstituted sesquiterpenes daucanes from the wild Daucus carota
AU - Ahmed, Ahmed A.
AU - Bishr, Mohktar M.
AU - El-Shanawany, Mohamed A.
AU - Attia, Eman Z.
AU - Ross, Samir A.
AU - Paré, Paul W.
N1 - Funding Information:
The work was supported by The Robert A. Welch Foundation at Texas Tech University (Grant D-1478). A.A.A. thanks the Alexander von Humboldt Stiftung for financial support for the HPLC instrument. The authors are grateful to Dr. Gazi Sultana (NCNPR, University of Mississippi) for the NMR analyses.
PY - 2005/7
Y1 - 2005/7
N2 - Phytochemical and biological investigation of the roots of the wild Daucus carota ssp. carota afforded three new and four known compounds, including four sesquiterpenes daucane esters (1-3 [new], and 4), one polyacetylene (5), one sesquiterpene coumarin (6), and sitosterol glucoside. The structures of the new compounds were determined by comprehensive NMR studies, including DEPT, COSY, NOESY, HMQC and HMBC analyses. Based on an agar diffusion assay, 1, 2 and 4-6 were screened and found to contain a range of low antibacterial activities against four gram positive (Staphylococcus aureus, Streptomyces scabies, Bacillus subtilus, Bacillus cereus) and two gram negative species (Pseudomonas aeruginosa, Escherichia coli) as well as antifungal against Fusarium oxysporum and Aspergillus niger using cup agar diffusion assay.
AB - Phytochemical and biological investigation of the roots of the wild Daucus carota ssp. carota afforded three new and four known compounds, including four sesquiterpenes daucane esters (1-3 [new], and 4), one polyacetylene (5), one sesquiterpene coumarin (6), and sitosterol glucoside. The structures of the new compounds were determined by comprehensive NMR studies, including DEPT, COSY, NOESY, HMQC and HMBC analyses. Based on an agar diffusion assay, 1, 2 and 4-6 were screened and found to contain a range of low antibacterial activities against four gram positive (Staphylococcus aureus, Streptomyces scabies, Bacillus subtilus, Bacillus cereus) and two gram negative species (Pseudomonas aeruginosa, Escherichia coli) as well as antifungal against Fusarium oxysporum and Aspergillus niger using cup agar diffusion assay.
KW - Antibacterial
KW - Apiaceae
KW - Daucane sesquiterpenes
KW - Daucus carota ssp. carota
KW - Polyacetylene
KW - Sesquiterpene coumarin
UR - http://www.scopus.com/inward/record.url?scp=22744434297&partnerID=8YFLogxK
U2 - 10.1016/j.phytochem.2005.05.010
DO - 10.1016/j.phytochem.2005.05.010
M3 - Article
C2 - 15964039
AN - SCOPUS:22744434297
SN - 0031-9422
VL - 66
SP - 1680
EP - 1684
JO - Phytochemistry
JF - Phytochemistry
IS - 14
ER -