Rare hydroperoxyl guaianolide sesquiterpenes from Pulicaria undulata

Mohamed Elamir F. Hegazy, Seikou Nakamura, Wafaa A. Tawfik, Nahla S. Abdel-Azim, Ahmed Abdel-Lateff, Hisashi Matsuda, Paul W. Paré

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Pulicaria species, such as Pulicaria undulata, are rich in sesquiterpene lactones. The methylene chloride/methanol (1:1) extract of P. undulata resulted in the isolation of new sesquiterpenes (1-4), as well as previously reported metabolites (5-14). Structures were elucidated by spectroscopic analyses. Using a mouse peritoneal macrophage bioassay, lipopolysaccharide-induced nitric oxide inhibition was observed with the eudesman-type sesquiterpene 1β,4β-dihydroxy-5αH,7αH,8α-guaia-10(14),11(13)-dien-8β,12-olide (11) at an EC50 of 7.2 μM.

Original languageEnglish
Pages (from-to)177-181
Number of pages5
JournalPhytochemistry Letters
StatePublished - Jun 1 2015


  • Asteraceae
  • Nitric oxide inhibition
  • Pulicaria undulate
  • RAW264.7 cells
  • Sesquiterpenoids

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    Hegazy, M. E. F., Nakamura, S., Tawfik, W. A., Abdel-Azim, N. S., Abdel-Lateff, A., Matsuda, H., & Paré, P. W. (2015). Rare hydroperoxyl guaianolide sesquiterpenes from Pulicaria undulata. Phytochemistry Letters, 12, 177-181. https://doi.org/10.1016/j.phytol.2015.03.019