TY - JOUR
T1 - Rare hydroperoxyl guaianolide sesquiterpenes from Pulicaria undulata
AU - Hegazy, Mohamed Elamir F.
AU - Nakamura, Seikou
AU - Tawfik, Wafaa A.
AU - Abdel-Azim, Nahla S.
AU - Abdel-Lateff, Ahmed
AU - Matsuda, Hisashi
AU - Paré, Paul W.
N1 - Publisher Copyright:
© 2015 Phytochemical Society of Europe.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Pulicaria species, such as Pulicaria undulata, are rich in sesquiterpene lactones. The methylene chloride/methanol (1:1) extract of P. undulata resulted in the isolation of new sesquiterpenes (1-4), as well as previously reported metabolites (5-14). Structures were elucidated by spectroscopic analyses. Using a mouse peritoneal macrophage bioassay, lipopolysaccharide-induced nitric oxide inhibition was observed with the eudesman-type sesquiterpene 1β,4β-dihydroxy-5αH,7αH,8α-guaia-10(14),11(13)-dien-8β,12-olide (11) at an EC50 of 7.2 μM.
AB - Pulicaria species, such as Pulicaria undulata, are rich in sesquiterpene lactones. The methylene chloride/methanol (1:1) extract of P. undulata resulted in the isolation of new sesquiterpenes (1-4), as well as previously reported metabolites (5-14). Structures were elucidated by spectroscopic analyses. Using a mouse peritoneal macrophage bioassay, lipopolysaccharide-induced nitric oxide inhibition was observed with the eudesman-type sesquiterpene 1β,4β-dihydroxy-5αH,7αH,8α-guaia-10(14),11(13)-dien-8β,12-olide (11) at an EC50 of 7.2 μM.
KW - Asteraceae
KW - Nitric oxide inhibition
KW - Pulicaria undulate
KW - RAW264.7 cells
KW - Sesquiterpenoids
UR - http://www.scopus.com/inward/record.url?scp=84927927975&partnerID=8YFLogxK
U2 - 10.1016/j.phytol.2015.03.019
DO - 10.1016/j.phytol.2015.03.019
M3 - Article
AN - SCOPUS:84927927975
SN - 1874-3900
VL - 12
SP - 177
EP - 181
JO - Phytochemistry Letters
JF - Phytochemistry Letters
ER -