Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution

Anne L. Van De Ven, Pilhan Kim, O'Hara Haley, Jean R. Fakhoury, Giulia Adriani, Jeffrey Schmulen, Padraig Moloney, Fazle Hussain, Mauro Ferrari, Xuewu Liu, Seok Hyun Yun, Paolo Decuzzi

Research output: Contribution to journalArticle

135 Scopus citations

Abstract

Nanoparticles for cancer therapy and imaging are designed to accumulate in the diseased tissue by exploiting the Enhanced Permeability and Retention (EPR) effect. This limits their size to about 100 nm. Here, using intravital microscopy and elemental analysis, we compare the in vivo localization of particles with different geometries and demonstrate that plateloid particles preferentially accumulate within the tumor vasculature at unprecedented levels, independent of the EPR effect. In melanoma-bearing mice, 1000 × 400 nm plateloid particles adhered to the tumor vasculature at about 5% and 10% of the injected dose per gram organ (ID/g) for untargeted and RGD-targeted particles respectively, and exhibited the highest tumor-to-liver accumulation ratios (0.22 and 0.35). Smaller and larger plateloid particles, as well as cylindroid particles, were more extensively sequestered by the liver, spleen, and lungs. Plateloid particles appeared well-suited for taking advantage of hydrodynamic forces and interfacial interactions required for efficient tumoritropic accumulation, even without using specific targeting ligands.

Original languageEnglish
Pages (from-to)148-155
Number of pages8
JournalJournal of Controlled Release
Volume158
Issue number1
DOIs
StatePublished - Feb 28 2012

Keywords

  • Biodistribution
  • Biodistribution
  • Intravital microscopy
  • Intravital microscopy
  • Nanoparticles
  • Nanoparticles
  • Rational design
  • Rational design
  • Size and shape
  • Size and shape
  • Tumor accumulation
  • Tumor accumulation

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  • Cite this

    Van De Ven, A. L., Kim, P., Haley, OH., Fakhoury, J. R., Adriani, G., Schmulen, J., Moloney, P., Hussain, F., Ferrari, M., Liu, X., Yun, S. H., & Decuzzi, P. (2012). Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution. Journal of Controlled Release, 158(1), 148-155. https://doi.org/10.1016/j.jconrel.2011.10.021