Rapid, cost-efficient fabrication of microfluidic reactors in thermoplastic polymers by combining photolithography and hot embossing

Jesse Greener, Wei Li, Judy Ren, Dan Voicu, Viktoriya Pakharenko, Tian Tang, Eugenia Kumacheva

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

We report a cost-efficient and easy to implement process for fabricating microfluidic reactors in thermoplastic materials. The method includes (i) the fabrication of an imprint template (master), which consists of a photoresist deposited on a metal plate; (ii) the thermoembossing of the reactor features into polymer sheets; (iii) the activation of the embossed and planar thermoplastic surfaces; and (iv) the low-temperature bonding of these surfaces. The generality of the method is established by fabricating microfluidic reactors with a complex geometry in a range of thermoplastic polymers, including cycloolefin, polycarbonate, and UV-transparent acrylic polymers and by the multiple, high-fidelity use of the master.

Original languageEnglish
Pages (from-to)522-524
Number of pages3
JournalLab on a Chip
Volume10
Issue number4
DOIs
StatePublished - 2010

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