Questioning the role of rebound firing in the cerebellum

Karina Alvĩa, Joy T. Walter, Adam Kohn, Graham Ellis-Davies, Kamran Khodakhah

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


A key component of recent theories on cerebellar function is rebound firing in neurons of the deep cerebellar nuclei (DCN). Despite the robustness of this phenomenon in vitro, in vivo studies have provided little evidence for its prevalence. We found that intact mouse or rat DCN neurons rarely showed rebound firing under physiological conditions in vitro or in vivo. These observations necessitate a critical re-evaluation of recent cerebellar models.

Original languageEnglish
Pages (from-to)1256-1258
Number of pages3
JournalNature Neuroscience
Issue number11
StatePublished - Nov 2008


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