Quantifying human atherosclerotic plaque growth function using multi-year in vivo MRI and meshless local Petrov-Galerkin method

Dalin Tang, Chun Yang, Joseph D. Petruccelli, Chun Yuan, Fei Liu, Tom Hatsukami, Sayan Mondal, Satya Atluri

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Atherosclerosis is a disease in human circulation system affecting a large percentage of people, especially elderly people in the developed countries. To better predict plaque progression and prevent potential rupture, multi-year MRI patient-tracking data were obtained to quantify human atherosclerotic plaque progression. MRI-based 2D/3D models with multi-component plaque structure and fluid-structure interactions (FSI) were developed and solved by numerical methods based on the meshless local Petrov-Galerkin (MLPG) method (2D) and finite element method (2D/3D) to quantify plaque growth functions which can be used to simulate plaque progression for early prediction and diagnosis of atherosclerosis-related cardiovascular diseases. For the first time, quantitative human plaque growth functions were determined using structure stress and flow shear stress data. Use of multi-year data leads to verifiable simulations and improved accuracy of predictions. Our initial results support the new hypothesis that plaque progression has negative correlation with structural stress and flow shear stress conditions. Plaque growth functions using both structure stress and flow shear stress leads to much better agreement with patient plaque progression data than using either of them. More data and validations are needed to confirm our findings.

Original languageEnglish
Title of host publication2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007
Pages546-551
Number of pages6
DOIs
StatePublished - 2007
Event2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007 - Beijing, China
Duration: May 23 2007May 27 2007

Publication series

Name2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007

Conference

Conference2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007
CountryChina
CityBeijing
Period05/23/0705/27/07

Keywords

  • Atherosclerosis
  • Blood flow
  • Carotid artery
  • Fluid-structure interaction
  • Meshless method
  • Plaque progression

Fingerprint Dive into the research topics of 'Quantifying human atherosclerotic plaque growth function using multi-year in vivo MRI and meshless local Petrov-Galerkin method'. Together they form a unique fingerprint.

Cite this