TY - JOUR
T1 - Protective properties of n-3 fatty acids and implications in obesity-associated breast cancer
AU - AL-Jawadi, Arwa
AU - Moussa, Hanna
AU - Ramalingam, Latha
AU - Dharamawardhane, Suranganie
AU - Gollahon, Lauren
AU - Gunaratne, Preethi
AU - Layeequr Rahman, Rakhshanda
AU - Moustaid-Moussa, Naima
N1 - Funding Information:
This work was supported by start-up funds from Texas Tech University (N.M.M., H.M., L.R.) and by pilot and feasibility funds from the Obesity Research Cluster (N.M.M., H.M., L.G., S.D., P.G., L.R.).
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/3
Y1 - 2018/3
N2 - Obesity is well documented as a risk factor for developing breast cancer, especially in postmenopausal women. Adipose tissue in the breast under obese conditions induces inflammation by increasing macrophage infiltration and pro-inflammatory cytokines that in turn up-regulates genes and signaling pathways, resulting in increased inflammation, cell proliferation and tumor growth in the breast. Due to their potent anti-inflammatory effects, n-3 polyunsaturated fatty acids (n-3 PUFA) are a promising and safe dietary intervention in reducing breast cancer risk. Here, we briefly review current status of breast cancer and its relationship with obesity. We then review in depth, current research and knowledge on the role of n-3 PUFA in reducing/preventing breast cancer cell growth in vitro, in vivo and in human studies, and how n-3 PUFA may modulate signaling pathways mitigating their effects on breast cancer development.
AB - Obesity is well documented as a risk factor for developing breast cancer, especially in postmenopausal women. Adipose tissue in the breast under obese conditions induces inflammation by increasing macrophage infiltration and pro-inflammatory cytokines that in turn up-regulates genes and signaling pathways, resulting in increased inflammation, cell proliferation and tumor growth in the breast. Due to their potent anti-inflammatory effects, n-3 polyunsaturated fatty acids (n-3 PUFA) are a promising and safe dietary intervention in reducing breast cancer risk. Here, we briefly review current status of breast cancer and its relationship with obesity. We then review in depth, current research and knowledge on the role of n-3 PUFA in reducing/preventing breast cancer cell growth in vitro, in vivo and in human studies, and how n-3 PUFA may modulate signaling pathways mitigating their effects on breast cancer development.
KW - Breast cancer
KW - Exosomes
KW - Inflammation
KW - N-3 fatty acids
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85032451246&partnerID=8YFLogxK
U2 - 10.1016/j.jnutbio.2017.09.018
DO - 10.1016/j.jnutbio.2017.09.018
M3 - Review article
C2 - 29096149
AN - SCOPUS:85032451246
VL - 53
SP - 1
EP - 8
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
SN - 0955-2863
ER -