Protective effects of eicosapentaenoic acid in adipocyte-breast cancer cell cross talk

Arwa aL-jAWADI, Fahmida Rasha, Latha Ramalingam, Sara Alhaj, Hanna Moussa, Lauren Gollahon, Suranganie Dharmawardhane, Naima Moustaid-Moussa

Research output: Contribution to journalArticlepeer-review

Abstract

Breast cancer is the leading cause of death in women among all cancer types. Obesity is one of the factors that promote progression of breast cancer, especially in post-menopausal women. Increasingly, adipose tissue is recognized for its active role in the tumor microenvironment. We hypothesized that adipocytes conditioned medium can impact breast cancer progression by increasing inflammatory cytokines production by cancer cells, and subsequently increasing their motility. By contrast, eicosapentaenoic acid (EPA), an anti-inflammatory n-3 polyunsaturated fatty acid, reduces adipocyte-secreted inflammatory factors, leading to reduced cancer cell motility. To test these hypotheses, we investigated the direct effects of EPA on MCF-7 and MDA-MB-231 breast cancer cells and the effects of conditioned medium from 3 T3-L1 or human mesenchymal stem cells (HMSC)-derived adipocytes treated with or without EPA supplementation on breast cancer cells. We observed that conditioned medium from HMSC-d
Original languageEnglish
Pages (from-to)8
JournalJournal of Nutritional Biochemistry
DOIs
StatePublished - Jan 2020

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