TY - JOUR
T1 - Propagating waves in visual cortex
T2 - A large-scale model of turtle visual cortex
AU - Nenadic, Zoran
AU - Ghosh, Bijoy K.
AU - Ulinski, Philip
PY - 2003
Y1 - 2003
N2 - This article describes a large-scale model of turtle visual cortex that simulates the propagating waves of activity seen in real turtle cortex. The cortex model contains 744 multicompartment models of pyramidal cells, stellate cells, and horizontal cells. Input is provided by an array of 201 geniculate neurons modeled as single compartments with spike-generating mechanisms and axons modeled as delay lines. Diffuse retinal flashes or presentation of spots of light to the retina are simulated by activating groups of geniculate neurons. The model is limited in that it does not have a retina to provide realistic input to the geniculate, and the cortex and does not incorporate all of the biophysical details of real cortical neurons. However, the model does reproduce the fundamental features of planar propagating waves. Activation of geniculate neurons produces a wave of activity that originates at the rostrolateral pole of the cortex at the point where a high density of geniculate afferents enter the cortex. Waves propagate across the cortex with velocities of 4 μm/ms to 70 μm/ms and occasionally reflect from the caudolateral border of the cortex.
AB - This article describes a large-scale model of turtle visual cortex that simulates the propagating waves of activity seen in real turtle cortex. The cortex model contains 744 multicompartment models of pyramidal cells, stellate cells, and horizontal cells. Input is provided by an array of 201 geniculate neurons modeled as single compartments with spike-generating mechanisms and axons modeled as delay lines. Diffuse retinal flashes or presentation of spots of light to the retina are simulated by activating groups of geniculate neurons. The model is limited in that it does not have a retina to provide realistic input to the geniculate, and the cortex and does not incorporate all of the biophysical details of real cortical neurons. However, the model does reproduce the fundamental features of planar propagating waves. Activation of geniculate neurons produces a wave of activity that originates at the rostrolateral pole of the cortex at the point where a high density of geniculate afferents enter the cortex. Waves propagate across the cortex with velocities of 4 μm/ms to 70 μm/ms and occasionally reflect from the caudolateral border of the cortex.
KW - Cortical waves
KW - Karhunen-Loéve decomposition
KW - Large-scale model
KW - Visual cortex
UR - http://www.scopus.com/inward/record.url?scp=0037334566&partnerID=8YFLogxK
U2 - 10.1023/A:1021954701494
DO - 10.1023/A:1021954701494
M3 - Article
C2 - 12567015
AN - SCOPUS:0037334566
SN - 0929-5313
VL - 14
SP - 161
EP - 184
JO - Journal of Computational Neuroscience
JF - Journal of Computational Neuroscience
IS - 2
ER -