Abstract
Establishment or spread of a viral infection within healthy individuals depends on exposure to a viral source, either through virus particles or through cells that have been infected. We assume that a potential infection has reached the site of the healthy target cells and we apply stochastic within-host models and multitype branching processes to investigate whether a major infection becomes established. The model includes multiple latent and actively infected stages. It is shown that the probability of a major infection is generally more likely after the virus has entered the target cell and the cell is actively infected. In some cases, the probability of a major infection is less likely if the burst size of actively infected cells is small.
Original language | English |
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Pages (from-to) | 1-6 |
Number of pages | 6 |
Journal | Applied Mathematics Letters |
Volume | 87 |
DOIs | |
State | Published - Jan 2019 |
Keywords
- Branching process
- Markov chain
- Viral infection
- Within-host models