TY - JOUR
T1 - Presqualene alcohol, squalene, and sterol biosynthesis from bifarnesol
AU - Nes, W. David
AU - Le, Phu
AU - van Tamelen, Eugene E.
AU - Leopold, Eric J.
PY - 1990/3
Y1 - 1990/3
N2 - To cast light on the overall biosynthetic conversion of farnesol pyrophosphate to presqualene alcohol pyrophosphate (PSA), the biochemical precursor of squalene as well as all sterols, radiolabeled bifarnesol (1) was prepared and fed toGibberella fujikuroi. The diol (1), acting as a surrogate for a previously suggested phosphorylated version of1, was converted to radiolabeled presqualene alcohol and squalene, as well as various sterols, including lanosterol and24-β-methylcholesta-5,7,9(11),22-tetraen-3β-ol, previously isolated from the same fungus. The results are interpreted to imply that a phosphorylated version of1 may act as a bone fide intermediate in the biosynthesis of PSA, thereby rendering unlikely any type of concerted farnesyl/presqualene pyrophosphate change.
AB - To cast light on the overall biosynthetic conversion of farnesol pyrophosphate to presqualene alcohol pyrophosphate (PSA), the biochemical precursor of squalene as well as all sterols, radiolabeled bifarnesol (1) was prepared and fed toGibberella fujikuroi. The diol (1), acting as a surrogate for a previously suggested phosphorylated version of1, was converted to radiolabeled presqualene alcohol and squalene, as well as various sterols, including lanosterol and24-β-methylcholesta-5,7,9(11),22-tetraen-3β-ol, previously isolated from the same fungus. The results are interpreted to imply that a phosphorylated version of1 may act as a bone fide intermediate in the biosynthesis of PSA, thereby rendering unlikely any type of concerted farnesyl/presqualene pyrophosphate change.
UR - http://www.scopus.com/inward/record.url?scp=0025333139&partnerID=8YFLogxK
U2 - 10.1016/0147-5975(90)90088-B
DO - 10.1016/0147-5975(90)90088-B
M3 - Article
AN - SCOPUS:0025333139
SN - 0147-5975
VL - 14
SP - 74
EP - 77
JO - Experimental Mycology
JF - Experimental Mycology
IS - 1
ER -