TY - JOUR
T1 - Preparation of 2,7-diamino-1,8-naphthyridine
T2 - A useful building block for supramolecular chemistry
AU - Park, Taiho
AU - Mayer, Michael F.
AU - Nakashima, Shoji
AU - Zimmerman, Steven C.
PY - 2005/6/1
Y1 - 2005/6/1
N2 - A two-step conversion of 2-chloro-7-amido-1,8-naphthyridine to 2,7-diamino-1,8-naphthyridine is described. The process, which involves a nucleophilic aromatic substitution reaction with 4-methoxybenzylamine and subsequent deprotection, can be carried out on a large scale.
AB - A two-step conversion of 2-chloro-7-amido-1,8-naphthyridine to 2,7-diamino-1,8-naphthyridine is described. The process, which involves a nucleophilic aromatic substitution reaction with 4-methoxybenzylamine and subsequent deprotection, can be carried out on a large scale.
KW - Amine protecting group
KW - Heterocycles
KW - Hydrogen bond
KW - Nucleophilic aromatic substitution
KW - Supramolecular systems
UR - http://www.scopus.com/inward/record.url?scp=20544441692&partnerID=8YFLogxK
U2 - 10.1055/s-2005-868507
DO - 10.1055/s-2005-868507
M3 - Article
AN - SCOPUS:20544441692
SN - 0936-5214
SP - 1435
EP - 1436
JO - Synlett
JF - Synlett
IS - 9
ER -