Preparation of 2,7-diamino-1,8-naphthyridine: A useful building block for supramolecular chemistry

Taiho Park, Michael F. Mayer, Shoji Nakashima, Steven C. Zimmerman

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

A two-step conversion of 2-chloro-7-amido-1,8-naphthyridine to 2,7-diamino-1,8-naphthyridine is described. The process, which involves a nucleophilic aromatic substitution reaction with 4-methoxybenzylamine and subsequent deprotection, can be carried out on a large scale.

Original languageEnglish
Pages (from-to)1435-1436
Number of pages2
JournalSynlett
Issue number9
DOIs
StatePublished - Jun 1 2005

Keywords

  • Amine protecting group
  • Heterocycles
  • Hydrogen bond
  • Nucleophilic aromatic substitution
  • Supramolecular systems

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