Preparation and characterization of macroporous poly(N-isopropylacrylamide) hydrogels for the controlled release of proteins

Ren Xi Zhuo, Wei Li

Research output: Contribution to journalArticlepeer-review

107 Scopus citations

Abstract

Macroporous, temperature-sensitive poly(N-isopropylacrylamide.) (PNIPAAm) hydrogels were synthesized with poly(ethylene glycol)s (PEGs; molecular weight = 2000-6000) as the pore-forming agents. The influence of the molecular weight and PEG content on the responsive kinetics of these macroporous hydrogels was investigated. The PEG-modified PNIPAAm hydrogels were characterized by the swelling ratio, deswelling-reswelling kinetics, Fourier transform infrared, and differential scanning calorimetry. The morphology of these hydrogels was analyzed with scanning electron microscopy. The prepared macroporous hydrogels exhibited some unique properties in comparison with the gels with low molecular weight PEGs (molecular weight < 2000) as the pore-forming agents. In addition, a preliminary study on the controlled release of bovine serum albumin from these macroporous hydrogels was carried out.

Original languageEnglish
Pages (from-to)152-159
Number of pages8
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume41
Issue number1
DOIs
StatePublished - Jan 1 2002

Keywords

  • Controlled release
  • Hydrogels
  • Kinetics (polym)
  • Macroporous polymers
  • Poly(N-isopropylacrylamide) (PNIPAAm)

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