The use of power cepstrum analysis in image registration is explored. Rotational shifts and translational shifts are corrected separately. The technique involves two main ideas. First, after preprocessing to remove extraneous information and information which could result in false registration parameters, a rotational shift is changed into a translational shift by using the shift-invariant property of the power spectrum. Second, power cepstrum analysis is used to correct the translational shift. Because of the introduction of these ideas, this new algorithm can work very fast and accurately compared to conventional correlation techniques. This registration technique is applied to sequential fundus images with potential application in detecting changes in fundus anomalies.