@article{671d34af8e00428c8cdf6b708099c805,
title = "Possibility for reverse zoonotic transmission of sars-cov-2 to free-ranging wildlife: A case study of bats",
abstract = "The COVID-19 pandemic highlights the substantial public health, economic, and societal consequences of virus spillover from a wildlife reservoir. Widespread human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also presents a new set of challenges when considering viral spillover from people to na{\"i}ve wildlife and other animal populations. The establishment of new wildlife reservoirs for SARS-CoV-2 would further complicate public health control measures and could lead to wildlife health and conservation impacts. Given the likely bat origin of SARS-CoV-2 and related beta-coronaviruses (β-CoVs), free-ranging bats are a key group of concern for spillover from humans back to wildlife. Here, we review the diversity and natural host range of β-CoVs in bats and examine the risk of humans inadvertently infecting free-ranging bats with SARS-CoV-2. Our review of the global distribution and host range of β-CoV evolutionary lineages suggests that 40+ species of temperate-zone North American bats could be immunologically na{\"i}ve and susceptible to infection by SARS-CoV-2. We highlight an urgent need to proactively connect the wellbeing of human and wildlife health during the current pandemic and to implement new tools to continue wildlife research while avoiding potentially severe health and conservation impacts of SARS-CoV-2 {"}spilling back{"} into free-ranging bat populations.",
author = "Olival, {Kevin J.} and Cryan, {Paul M.} and Amman, {Brian R.} and Baric, {Ralph S.} and Blehert, {David S.} and Brook, {Cara E.} and Calisher, {Charles H.} and Castle, {Kevin T.} and Coleman, {Jeremy T.H.} and Peter Daszak and Epstein, {Jonathan H.} and Hume Field and Frick, {Winifred F.} and Gilbert, {Amy T.} and Hayman, {David T.S.} and Ip, {Hon S.} and Karesh, {William B.} and Johnson, {Christine K.} and Kading, {Rebekah C.} and Tigga Kingston and Lorch, {Jeffrey M.} and Mendenhall, {Ian H.} and Peel, {Alison J.} and Phelps, {Kendra L.} and Plowright, {Raina K.} and Reeder, {Dee Ann M.} and Reichard, {Jonathan D.} and Sleeman, {Jonathan M.} and Streicker, {Daniel G.} and Towner, {Jonathan S.} and Wang, {Lin Fa}",
note = "Funding Information: This work was supported in part by the USGS John Wesley Powell Center for Analysis and Synthesis, National Institute of Allergy and Infectious Diseases of the National Institutes of Health (Award Number R01AI110964), and the US Department of Defense, Defense Threat Reduction Agency (HDTRA11710064). Funding for DTSH was provided by a Royal Society Te Aparangi grant RDF-MAU1701. Funding for DGS was provided by a Wellcome Trust Senior Research Fellowship (217221/Z/19/Z). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.",
year = "2020",
month = sep,
doi = "10.1371/journal.ppat.1008758",
language = "English",
volume = "16",
journal = "PLoS Pathogens",
issn = "1553-7366",
publisher = "PLoS pathogens",
number = "9",
}