Polydopamine-Assisted Surface Modification for Bone Biosubstitutes

Shishu Huang, Nuanyi Liang, Yang Hu, Xin Zhou, Noureddine Abidi

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

Polydopamine (PDA) prepared in the form of a layer of polymerized dopamine (DA) in a weak alkaline solution has been used as a versatile biomimetic surface modifier as well as a broadly used immobilizing macromolecule. This review mainly discusses the progress of biomaterial surface modification inspired by the participation of PDA in bone tissue engineering. A comparison between PDA-assisted coating techniques and traditional surface modification applied to bone tissue engineering is first presented. Secondly, the chemical composition and the underlying formation mechanism of PDA coating layer as a unique surface modifier are interpreted and discussed. Furthermore, several typical examples are provided to evidence the importance of PDA-assisted coating techniques in the construction of bone biosubstitutes and the improvement of material biocompatibility. Nowadays, the application of PDA as a superior surface modifier in multifunctional biomaterials is drawing tremendous interests in bone tissue scaffolds to promote the osteointegration for bone regeneration.

Original languageEnglish
Article number2389895
JournalBioMed Research International
Volume2016
DOIs
StatePublished - 2016

Fingerprint Dive into the research topics of 'Polydopamine-Assisted Surface Modification for Bone Biosubstitutes'. Together they form a unique fingerprint.

  • Cite this