Polar overdominance at the ovine callipyge locus

Noelle E. Cockett, Sam P. Jackson, Tracy L. Shay, Frédéric Farnir, Stéphane Berghmans, Gary D. Snowder, Dahlia M. Nielsen, Michel Georges

Research output: Contribution to journalArticlepeer-review

224 Scopus citations


An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge gene mapped to ovine chromosome 18. Here, the callipyge phenotype was found to be characterized by a nonmendelian inheritance pattern, referred to as polar overdominance, where only heterozygous individuals having inherited the callipyge mutation from their sire express the phenotype. The possible role of parental imprinting in the determinism of polar overdominance is envisaged.

Original languageEnglish
Pages (from-to)236-238
Number of pages3
Issue number5272
StatePublished - Jul 12 1996


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