Polar overdominance at the ovine callipyge locus

Noelle E. Cockett; Sam P. Jackson; Tracy L. Shay; Frédéric Farnir; Stéphane Berghmans; Gary D. Snowder; Dahlia M. Nielsen; Michel Georges

doi:10.1126/science.273.5272.236

Polar overdominance at the ovine callipyge locus

Noelle E. Cockett, Sam P. Jackson, Tracy L. Shay, Frédéric Farnir, Stéphane Berghmans, Gary D. Snowder, Dahlia M. Nielsen, Michel Georges

Animal and Food Sciences

Research output: Contribution to journal › Article › peer-review

227 Scopus citations

Abstract

An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge gene mapped to ovine chromosome 18. Here, the callipyge phenotype was found to be characterized by a nonmendelian inheritance pattern, referred to as polar overdominance, where only heterozygous individuals having inherited the callipyge mutation from their sire express the phenotype. The possible role of parental imprinting in the determinism of polar overdominance is envisaged.

Original language	English
Pages (from-to)	236-238
Number of pages	3
Journal	Science
Volume	273
Issue number	5272
DOIs	https://doi.org/10.1126/science.273.5272.236
State	Published - Jul 12 1996

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abstract = "An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge gene mapped to ovine chromosome 18. Here, the callipyge phenotype was found to be characterized by a nonmendelian inheritance pattern, referred to as polar overdominance, where only heterozygous individuals having inherited the callipyge mutation from their sire express the phenotype. The possible role of parental imprinting in the determinism of polar overdominance is envisaged.",

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AU - Cockett, Noelle E.

AU - Jackson, Sam P.

AU - Shay, Tracy L.

AU - Farnir, Frédéric

AU - Berghmans, Stéphane

AU - Snowder, Gary D.

AU - Nielsen, Dahlia M.

AU - Georges, Michel

PY - 1996/7/12

Y1 - 1996/7/12

N2 - An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge gene mapped to ovine chromosome 18. Here, the callipyge phenotype was found to be characterized by a nonmendelian inheritance pattern, referred to as polar overdominance, where only heterozygous individuals having inherited the callipyge mutation from their sire express the phenotype. The possible role of parental imprinting in the determinism of polar overdominance is envisaged.

AB - An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge gene mapped to ovine chromosome 18. Here, the callipyge phenotype was found to be characterized by a nonmendelian inheritance pattern, referred to as polar overdominance, where only heterozygous individuals having inherited the callipyge mutation from their sire express the phenotype. The possible role of parental imprinting in the determinism of polar overdominance is envisaged.

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Polar overdominance at the ovine callipyge locus

Abstract

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