San Josecito Cave is located on a steep western flank of the Sierra Madre Oriental, Nuevo Leon, Mexico, at 2250 m elevation. A total of 1115 skeletal remains of lizards are known from the deposit; only two specimens were from previous excavations. In greater than 100,000 vertebrate remains, only four species of lizards have been recovered: one anguid (Barisia cf. B. imbricata, n = 1088 fossils) and three phrynosomatids (Phrynosoma josecitensis, n = 1; P. orbiculare, n = 1; P. cf. P orbiculare, n = 12; and Sceloporus sp., n = 13). The cave has produced the type and only known specimen of the extinct species Phrynosoma josecitensis, described from an earlier excavation. The presence of, or the validity of, this extinct species cannot be verified on the basis of remains recovered from the current excavation, and the taxon may be a variant of the locally living P. orbiculare. The first fossil record of Barisia imbricata is presented.