Platelet-rich plasma: A Milieu of Bioactive Factors

Stacie G. Boswell, Brian J. Cole, Emily Sundman, Vasili Karas, Lisa A. Fortier

Research output: Contribution to journalArticlepeer-review


Platelet concentrates such as platelet-rich plasma (PRP) have gained popularity in sports medicine and orthopaedics to promote accelerated physiologic healing and return to function. Each PRP product varies depending on patient factors and the system used to generate it. Blood from some patients may fail to make PRP, and most clinicians use PRP without performing cell counts on either the blood or the preparation to confirm that the solution is truly PRP. Components in this milieu have bioactive functions that affect musculoskeletal tissue regeneration and healing. Platelets are activated by collagen or other molecules and release growth factors from alpha granules. Additional substances are released from dense bodies and lysosomes. Soluble proteins also present in PRP function in hemostasis, whereas others serve as biomarkers of musculoskeletal injury. Electrolytes and soluble plasma hormones are required for cellular signaling and regulation. Leukocytes and erythrocytes are present
Original languageEnglish
Pages (from-to)429-439
JournalArthroscopy - Journal of Arthroscopic and Related Surgery
StatePublished - Mar 1 2012


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