Plant Sterol Methyltransferases: Phytosterolomic Analysis, Enzymology, and Bioengineering Strategies

Wenxu Zhou, Henry T. Nguyen, W. David Nes

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

6 Scopus citations

Abstract

So far as is known, the biosynthesis of phytosterols is a ubiquitous property of plants and microbes, whereas insects fail to synthesize the sterol nucleus. All of them require phytosterols to grow and mature. In recent years, the availability of stable isotopes, modern instrumentation such as high-field nuclear magnetic resonance spectroscopy and molecular biology have offered new insights into the evolutionary development of sterol structure-enzyme function relationships, pathway sequencing, chemical ecology, and in the case of bioengineering provides a mechanism to generate value-added traits. Here we describe results obtained with these techniques in relation to the critical enzyme that controls the pattern of C-24 side-chain diversity, the (S)-adenosyl-L-methionine: Δ24-sterol methyltransferase (SMT).

Original languageEnglish
Title of host publicationAdvances in Plant Biochemistry and Molecular Biology
Pages241-281
Number of pages41
EditionC
DOIs
StatePublished - 2008

Publication series

NameAdvances in Plant Biochemistry and Molecular Biology
NumberC
Volume1
ISSN (Print)1755-0408

Keywords

  • Cholesterol
  • Phytosterol biosynthesis
  • Sitosterol
  • Sterol biosynthesis
  • Sterol methyltransferase

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