Physiological Basis for Creatine Supplementation in Skeletal Muscle

William J. Kraemer, Hui Ying Luk, Joel R. Lombard, Courtenay Dunn-Lewis, Jeff S. Volek

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Creatine (methylguanidino acetic acid) is one of the safest, most extensively studied, and popular supplements in the sports science community. Its primary role is to improve bioenergetics; by mediating phosphagen metabolism, creatine improves the availability of ATP for the myosin motor and improves force and power production. With resistance training, creatine-loaded muscle allows for a higher quality of training (e.g., more reps at a given weight, higher power output) that leads to more rapid training performance gains and muscle fiber hypertrophy. Creatine has therefore allowed an enhancement of muscle function and more rapid training gains within the genetic capabilities of the individual. Its role in endurance exercise is not well described but shows potential benefits for increased exercise economy at submaximal intensities. Finally, creatine supplementation may have important implications for aging as well as for muscle wasting and insulin resistance.

Original languageEnglish
Title of host publicationNutrition and Enhanced Sports Performance
Subtitle of host publicationMuscle Building, Endurance, and Strength
PublisherElsevier Inc.
Pages385-394
Number of pages10
ISBN (Print)9780123964540
DOIs
StatePublished - Aug 2013

Keywords

  • Bioenergetics
  • Ergogenic aids
  • Exercise performance
  • Muscle damage
  • Muscle fiber hypertrophy
  • Power
  • Resistance exercise
  • Sport science

Fingerprint Dive into the research topics of 'Physiological Basis for Creatine Supplementation in Skeletal Muscle'. Together they form a unique fingerprint.

  • Cite this

    Kraemer, W. J., Luk, H. Y., Lombard, J. R., Dunn-Lewis, C., & Volek, J. S. (2013). Physiological Basis for Creatine Supplementation in Skeletal Muscle. In Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength (pp. 385-394). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-396454-0.00039-4