Physiological Basis for Creatine Supplementation in Skeletal Muscle

William J. Kraemer, Hui Ying Luk, Joel R. Lombard, Courtenay Dunn-Lewis, Jeff S. Volek

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations


Creatine (methylguanidino acetic acid) is one of the safest, most extensively studied, and popular supplements in the sports science community. Its primary role is to improve bioenergetics; by mediating phosphagen metabolism, creatine improves the availability of ATP for the myosin motor and improves force and power production. With resistance training, creatine-loaded muscle allows for a higher quality of training (e.g., more reps at a given weight, higher power output) that leads to more rapid training performance gains and muscle fiber hypertrophy. Creatine has therefore allowed an enhancement of muscle function and more rapid training gains within the genetic capabilities of the individual. Its role in endurance exercise is not well described but shows potential benefits for increased exercise economy at submaximal intensities. Finally, creatine supplementation may have important implications for aging as well as for muscle wasting and insulin resistance.

Original languageEnglish
Title of host publicationNutrition and Enhanced Sports Performance
Subtitle of host publicationMuscle Building, Endurance, and Strength
PublisherElsevier Inc.
Number of pages10
ISBN (Print)9780123964540
StatePublished - Aug 2013


  • Bioenergetics
  • Ergogenic aids
  • Exercise performance
  • Muscle damage
  • Muscle fiber hypertrophy
  • Power
  • Resistance exercise
  • Sport science


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