Photoredox-Catalzyed Halo-trifluoromethylation of 1,7-Enynes for Synthesis of 3,4-Dihydroquinolin-2(1H)-ones

Xin Yuan, Ming Wei Zheng, Zhe Chen Di, Yu Sheng Cui, Kai Qiang Zhuang, Long Zhou Qin, Zheng Fang, Jiang Kai Qiu, Guigen Li, Kai Guo

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

An efficient photoredox-catalyzed halo-trifluoromethylation reaction of 1,7-enynes has been developed under mild conditions. This photocatalytic protocol provides an efficient and functional strategy leading to CF 3 − and halogen-containing 3,4-dihydroquinolin-2(1H)-ones from a wide range of 1,7-enynes through two different radical pathways. The reaction mechanism was proposed based on the control experiments. (Figure presented.).

Original languageEnglish
Pages (from-to)1835-1845
Number of pages11
JournalAdvanced Synthesis and Catalysis
Volume361
Issue number8
DOIs
StatePublished - Apr 16 2019

Keywords

  • 1,7-enynes
  • halo-trifluoromethylation
  • photoredox
  • radical pathway

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