Phospholipid and sphingolipid metabolism in Leishmania

Kai Zhang, Stephen M. Beverley

Research output: Contribution to journalReview article

67 Scopus citations

Abstract

In many eukaryotes, phospholipids (PLs) and sphingolipids (SLs) are abundant membrane components and reservoirs for important signaling molecules. In Leishmania, the composition, metabolism, and function of PLs and SLs differ significantly from those in mammalian cells. Although only a handful of enzymes have been experimentally characterized, available data suggest many steps of PL/SL metabolism are critical for Leishmania viability and/or virulence, and could be a source for new drug targets. Further studies of genes involved in the synthesis (de novo and salvage) and degradation of PLs and SLs will reveal their diverse effects on Leishmania pathogenesis.

Original languageEnglish
Pages (from-to)55-64
Number of pages10
JournalMolecular and Biochemical Parasitology
Volume170
Issue number2
DOIs
StatePublished - Apr 2010

Keywords

  • Leishmania
  • Phospholipid
  • Plasmalogen
  • Sphingolipid
  • Trypanosoma
  • Virulence

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