Phosphate Starvation-Dependent Iron Mobilization Induces CLE14 Expression to Trigger Root Meristem Differentiation through CLV2/PEPR2 Signaling

Dolores Gutiérrez-Alanís, Lenin Yong-Villalobos, Pedro Jiménez-Sandoval, Fulgencio Alatorre-Cobos, Araceli Oropeza-Aburto, Javier Mora-Macías, Federico Sánchez-Rodríguez, Alfredo Cruz-Ramírez, Luis Herrera-Estrella

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35 Scopus citations

Abstract

Low inorganic phosphate (Pi) availability causes terminal differentiation of the root apical meristem (RAM), a phenomenon known as root meristem exhaustion or determined growth. Here, we report that the CLE14 peptide acts as a key player in this process. Low Pi stress induces iron mobilization in the RAM through the action of LPR1/LPR2, causing expression of CLE14 in the proximal meristem region. CLV2 and PEPR2 receptors perceive CLE14 and trigger RAM differentiation, with concomitant downregulation of SHR/SCR and PIN/AUXIN pathway. Our results reveal multiple steps of the molecular mechanism of one of the most physiologically important root nutrient responses.

Original languageEnglish
Pages (from-to)555-570.e3
JournalDevelopmental Cell
Volume41
Issue number5
DOIs
StatePublished - Jun 5 2017

Keywords

  • CLE peptides
  • cell differentiation
  • phosphate starvation
  • root development
  • root stem cells

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    Gutiérrez-Alanís, D., Yong-Villalobos, L., Jiménez-Sandoval, P., Alatorre-Cobos, F., Oropeza-Aburto, A., Mora-Macías, J., Sánchez-Rodríguez, F., Cruz-Ramírez, A., & Herrera-Estrella, L. (2017). Phosphate Starvation-Dependent Iron Mobilization Induces CLE14 Expression to Trigger Root Meristem Differentiation through CLV2/PEPR2 Signaling. Developmental Cell, 41(5), 555-570.e3. https://doi.org/10.1016/j.devcel.2017.05.009