Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice

Dabney K. Johnson; Eugene M. Rinchik; Naima Moustaid-Moussa; Darla R. Miller; Robert W. Williams; Edward J. Michaud; Monica M. Jablonski; Andrea Elberger; Kristen Hamre; Richard Smeyne; Elissa Chesler; Daniel Goldowitz

doi:10.1007/s11357-005-4131-3

Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice

Dabney K. Johnson, Eugene M. Rinchik, Naima Moustaid-Moussa, Darla R. Miller, Robert W. Williams, Edward J. Michaud, Monica M. Jablonski, Andrea Elberger, Kristen Hamre, Richard Smeyne, Elissa Chesler, Daniel Goldowitz

Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

With the goal of discovering genes that contribute to late-onset neurological and ocular disorders and also genes that extend the healthy life span in mammals, we are phenotyping mice carrying new mutations induced by the chemical N-ethyl-N-nitrosourea (ENU). The phenotyping plan includes basic behavioral, neurohistological, and vision testing in sibling cohorts of mice aged to 18 months, and then evaluation for markers of growth trajectory and stress response in these same cohorts aged up to 28 months. Statistical outliers are identified by comparison to test results of similar aged cohorts, and potential mutants are recovered for re-aging to confirm heritability of the phenotype.

Original language	English
Pages (from-to)	75-90
Number of pages	16
Journal	Age
Volume	27
Issue number	1
DOIs	https://doi.org/10.1007/s11357-005-4131-3
State	Published - Mar 2005

Keywords

Age-onset
ENU mutations
Longevity
Neurological disorders
Phenotype-screening

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10.1007/s11357-005-4131-3

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title = "Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice",

abstract = "With the goal of discovering genes that contribute to late-onset neurological and ocular disorders and also genes that extend the healthy life span in mammals, we are phenotyping mice carrying new mutations induced by the chemical N-ethyl-N-nitrosourea (ENU). The phenotyping plan includes basic behavioral, neurohistological, and vision testing in sibling cohorts of mice aged to 18 months, and then evaluation for markers of growth trajectory and stress response in these same cohorts aged up to 28 months. Statistical outliers are identified by comparison to test results of similar aged cohorts, and potential mutants are recovered for re-aging to confirm heritability of the phenotype.",

keywords = "Age-onset, ENU mutations, Longevity, Neurological disorders, Phenotype-screening",

author = "Johnson, {Dabney K.} and Rinchik, {Eugene M.} and Naima Moustaid-Moussa and Miller, {Darla R.} and Williams, {Robert W.} and Michaud, {Edward J.} and Jablonski, {Monica M.} and Andrea Elberger and Kristen Hamre and Richard Smeyne and Elissa Chesler and Daniel Goldowitz",

year = "2005",

month = mar,

doi = "10.1007/s11357-005-4131-3",

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AU - Johnson, Dabney K.

AU - Rinchik, Eugene M.

AU - Moustaid-Moussa, Naima

AU - Miller, Darla R.

AU - Williams, Robert W.

AU - Michaud, Edward J.

AU - Jablonski, Monica M.

AU - Elberger, Andrea

AU - Hamre, Kristen

AU - Smeyne, Richard

AU - Chesler, Elissa

AU - Goldowitz, Daniel

PY - 2005/3

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N2 - With the goal of discovering genes that contribute to late-onset neurological and ocular disorders and also genes that extend the healthy life span in mammals, we are phenotyping mice carrying new mutations induced by the chemical N-ethyl-N-nitrosourea (ENU). The phenotyping plan includes basic behavioral, neurohistological, and vision testing in sibling cohorts of mice aged to 18 months, and then evaluation for markers of growth trajectory and stress response in these same cohorts aged up to 28 months. Statistical outliers are identified by comparison to test results of similar aged cohorts, and potential mutants are recovered for re-aging to confirm heritability of the phenotype.

AB - With the goal of discovering genes that contribute to late-onset neurological and ocular disorders and also genes that extend the healthy life span in mammals, we are phenotyping mice carrying new mutations induced by the chemical N-ethyl-N-nitrosourea (ENU). The phenotyping plan includes basic behavioral, neurohistological, and vision testing in sibling cohorts of mice aged to 18 months, and then evaluation for markers of growth trajectory and stress response in these same cohorts aged up to 28 months. Statistical outliers are identified by comparison to test results of similar aged cohorts, and potential mutants are recovered for re-aging to confirm heritability of the phenotype.

KW - Age-onset

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Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice

Abstract

Keywords

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