Phase Partitioning of Biomolecules: Solubilities of Amino Acids

Chau‐Chyun ‐C Chen, Yizu Zhu, Lawrence B. Evans

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

The representation of phase equilibrium for amino acids, peptides, and proteins in solution is an important problem in the design and optimization of downstream processes for recovery of the biomolecules. This paper presents a molecular thermodynamic framework [1, 2] for the representation of the solubilities of amino acids and small peptides. With this framework, satisfactory results have been obtained in representing and predicting the solubilities of amino acids and small peptides in aqueous solution as functions of temperature, ionic strength, dipolar species concentrations, solvent compositions, and pH.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalBiotechnology Progress
Volume5
Issue number3
DOIs
StatePublished - Sep 1989

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