Pharmacodynamic study on the capacity of selenium to promote arsenic excretion in arsenicosis patients in Bangladesh

M. Alauddin, E. Stekolchik, J. E. Spallholz, S. Ahmed, B. Chakraborty, G. N. George, J. Gailer, H. Ahsan, P. F. La Porte

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Several animal model and human studies suggest that dietary selenium can counter toxicity of arsenic through the formation of seleno-bis(S-glutathionyl) arsinium [(GS)2 AsSe]- ion in hepatocytes and excreted through bile. To assess whether oral administration of sodium selenite promotes an increase in fecal excretion of arsenic, a limited pharmacodynamic study was carried out involving four arsenicosis patients in Bangladesh. Patients were selected based on the arsenic level in their drinking water, hair, nail samples and symptoms of diffuse melanosis. In this preliminary study, patients received sodium selenite as oral selenium supplement. Both arsenic and selenium levels have increased in urine and feces of patients in 48 hours after dosing of sodium selenite (800 μg). The enhancement in arsenic and selenium levels in urine and feces after dosing is in agreement with our hypothesis that selenium supplementation promotes excretion of arsenic and selenium through formation of [(GS)2 AsSe]-.

Original languageEnglish
Title of host publicationOne Century of the Discovery of Arsenicosis in Latin America (1914-2014)
Subtitle of host publicationAs 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment
PublisherCRC Press/Balkema
Pages491-494
Number of pages4
ISBN (Print)9781138001411
DOIs
StatePublished - 2014
Event5th International Congress on Arsenic in the Environment, As 2014 - Buenos Aires, Argentina
Duration: May 11 2014May 16 2014

Publication series

NameOne Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment

Conference

Conference5th International Congress on Arsenic in the Environment, As 2014
CountryArgentina
CityBuenos Aires
Period05/11/1405/16/14

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