Pharmacodynamic study of the selenium-mediated arsenic excretion in arsenicosis patients in Bangladesh

M. Alauddin, R. Cekovic, S. Alauddin, L. Bolevic, S. Saha, J. E. Spallholz, P. F. Laporte, S. Ahmed, H. Ahsan, J. Gailer, O. Ponomarenko, I. J. Pickering, S. P. Singh, G. N. George

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Since 1938 several investigators have confirmed antagonistic interaction whereby the administration of selenite mitigates arsenite toxicity in mammals. More recently a number of animal model and human studies have revealed that the bimolecular basis of this antagonism involves the glutathione mediated formation of major metabolite seleno-bis(S-glutathionyl)arsinium [(GS)2AsSe]-ion which is rapidly excreted through bile. To investigate whether the oral supplementation of sodium selenite will enhance the fecal excretion of arsenites in human, a limited pharmacodynamics study was carried out involving ten arsenicosis patients. However, data from five patients are reported here. Patients were screened for pre-existing hepatic diseases and they were excluded from the study. Subjects were selected based on the arsenic level in their household drinking water, hair, nail samples and diffuse melanosis symptoms. Patients received 77Se-labeled sodium selenite as oral supplement, which they ingested together with their arsenic-containing drinking water. Total selenium levels increased in both urine and feces following the co-administration of sodium selenite (800 µg). The patients receiving a placebo showed no change in their selenium excretion. The increase in selenium levels in feces and arsenic to some extent after dosing agrees with our hypothesis that selenium supplementation promotes co-excretion of arsenic and selenium through formation of [(GS)2AsSe]-in the bile.

Original languageEnglish
Title of host publicationEnvironmental Arsenic in a ChangingWorld - 7th International Congress and Exhibition Arsenic in the Environment, 2018
EditorsYong-Guan Zhu, Yong-Guan Zhu, Huaming Guo, Huaming Guo, Prosun Bhattacharya, Prosun Bhattacharya, Jochen Bundschuh, Arslan Ahmad, Arslan Ahmad, Arslan Ahmad, Ravi Naidu, Ravi Naidu
PublisherCRC Press/Balkema
Pages391-394
Number of pages4
ISBN (Print)9781138486096
DOIs
StatePublished - 2018
Event7th International Congress and Exhibition Arsenic in the Environment, 2018 - Beijing, China
Duration: Jul 1 2018Jul 6 2018

Publication series

NameEnvironmental Arsenic in a ChangingWorld - 7th International Congress and Exhibition Arsenic in the Environment, 2018

Conference

Conference7th International Congress and Exhibition Arsenic in the Environment, 2018
CountryChina
CityBeijing
Period07/1/1807/6/18

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