Peripheral vasodilation is reduced during exercise in perimenopausal women with elevated cardiovascular risk

Joaquin Gonzales, David J. Moore, Steriani Elavsky, David N. Proctor

Research output: Contribution to journalArticlepeer-review

Abstract

The menopause transition has a negative impact on peripheral dilation in response to various stimuli including shear stress and exercise. Whether the presence of elevated traditional cardiovascular disease (CVD) risk factors in women going through menopause exacerbates the adverse effect on peripheral vasodilation is unclear. Forty-four perimenopausal women with relatively low CVD risk were divided into tertiles based on ASCVD 10-year risk scores (lowest: 0.1-0.5%, middle: 0.6-0.9%, higher: >1%). Comparisons were made across tertile groups for the femoral artery vascular conductance (FVC) response to single-leg knee extension exercise (0W, 5W, 10W, 15W) as measured using Doppler ultrasound. At higher exercise intensities, FVC was lower in women in the tertile group with the highest ASCVD 10-year risk scores (10W: 6±2 ml/min/mmHg, 15W: 8±3 ml/min/mmHg) compared to women in the lowest tertile group (10W: 9±3 ml/min/mmHg, p=0.01; 15W: 12±3 ml/min/mmHg, p<0.01) and middle tertile group
Original languageEnglish
Pages (from-to)1167-1170
JournalMenopause
StatePublished - Oct 2020

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