Endoscopie surgery - a procedure wherein a target organ is displayed on a monitor and physicians use graspers to manipulate the tissue - has benefits for patients in terms of reduced blood loss, infection, and pain. However, physicians' informal reports indicate that this type of surgery is challenging to perform. These challenges arise from the need to view the target tissue on a monitor, resulting in reduced depth information as well as a disruption of the normal hand-eye mapping. This study represents the initial experimental effort to assess the workload demands experienced in an endoscopic surgery simulator using the NASA-Task Load Index (TLX), a well validated workload measure, and the Multiple Resource Questionnaire (MRQ), a newly developed workload scale. The TLX revealed that the workload experienced in the simulator was indeed high. Additionally, the MRQ revealed different workload profiles associated with different levels of handeye mapping disruption.