In this study the patterns of psychological responses and their association with economic losses and individuals' age were examined with a sample of respondents who experienced a devastating tornado in Joplin in 2011, which killed more than 160 people. The sample included 39 respondents mainly recruited from two major shelters in the aftermath of the storm. The latent class analysis identified three types of psychological responses, namely, those who experienced a low level of negative effects and a low level of psychological growth (G1), those who experienced a high level of negative effects and a high level of psychological growth (G2), and those who experienced a moderate level of negative effects and a high level of psychological growth (G3). Results from multinomial logistic regression showed that greater losses were associated with higher likelihood of membership in G3 than G1, but this effect was buffered by age. For the same amount of losses, older persons were less likely to have stronger psychological responses, both positive and negatively. These findings will provide useful guidance for federal and state agencies on improving effective disaster response and treatment strategies.