Patterns of genotoxicity and contaminant exposure: Evidence of genomic instability in the marsh frogs (Rana ridibunda) of Sumgayit, Azerbaijan

Cole W. Matson; Grigoriy M. Palatnikov; Thomas J. McDonald; Robin L. Autenrieth; K. C. Donnelly; Todd A. Anderson; Jaclyn E. Canas; Arif Islamzadeh; John W. Bickham

doi:10.1897/04-250R1.1

Patterns of genotoxicity and contaminant exposure: Evidence of genomic instability in the marsh frogs (Rana ridibunda) of Sumgayit, Azerbaijan

Cole W. Matson, Grigoriy M. Palatnikov, Thomas J. McDonald, Robin L. Autenrieth, K. C. Donnelly, Todd A. Anderson, Jaclyn E. Canas, Arif Islamzadeh, John W. Bickham

Environmental Toxicology

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20 Scopus citations

Abstract

The wetlands of Sumgayit in the Azerbaijan Republic contain complex mixtures of contaminants, including polycyclic aromatic hydrocarbons (PAHs), mercury, organochlorine pesticides, and polychlorinated biphenyls. Marsh frogs (Rana ridibunda) were collected from several contaminated wetlands within the city as well as from two reference sites outside the city. Sediment samples revealed heterogeneous patterns of PAH and mercury concentrations throughout Sumgayit, with the highest levels occurring east of the Sumgayit River, within the industrial zone. Flow cytometry and micronucleus assay revealed elevated estimates of genetic damage in frogs from the wetlands east of the Sumgayit River compared to frogs from the reference sites. Flow cytometric data showed a significant correlation with sediment mercury concentrations, whereas population micronucleus frequencies were significantly correlated with high-molecular-weight PAHs.

Original language	English
Pages (from-to)	2055-2064
Number of pages	10
Journal	Environmental Toxicology and Chemistry
Volume	24
Issue number	8
DOIs	https://doi.org/10.1897/04-250R1.1
State	Published - Aug 2005

Keywords

Azerbaijan
Biomarkers
Flow cytometry
Micronucleus
Rana ridibunda

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10.1897/04-250R1.1

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Matson, C. W., Palatnikov, G. M., McDonald, T. J., Autenrieth, R. L., Donnelly, K. C., Anderson, T. A., Canas, J. E., Islamzadeh, A., & Bickham, J. W. (2005). Patterns of genotoxicity and contaminant exposure: Evidence of genomic instability in the marsh frogs (Rana ridibunda) of Sumgayit, Azerbaijan. Environmental Toxicology and Chemistry, 24(8), 2055-2064. https://doi.org/10.1897/04-250R1.1

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title = "Patterns of genotoxicity and contaminant exposure: Evidence of genomic instability in the marsh frogs (Rana ridibunda) of Sumgayit, Azerbaijan",

abstract = "The wetlands of Sumgayit in the Azerbaijan Republic contain complex mixtures of contaminants, including polycyclic aromatic hydrocarbons (PAHs), mercury, organochlorine pesticides, and polychlorinated biphenyls. Marsh frogs (Rana ridibunda) were collected from several contaminated wetlands within the city as well as from two reference sites outside the city. Sediment samples revealed heterogeneous patterns of PAH and mercury concentrations throughout Sumgayit, with the highest levels occurring east of the Sumgayit River, within the industrial zone. Flow cytometry and micronucleus assay revealed elevated estimates of genetic damage in frogs from the wetlands east of the Sumgayit River compared to frogs from the reference sites. Flow cytometric data showed a significant correlation with sediment mercury concentrations, whereas population micronucleus frequencies were significantly correlated with high-molecular-weight PAHs.",

keywords = "Azerbaijan, Biomarkers, Flow cytometry, Micronucleus, Rana ridibunda",

author = "Matson, {Cole W.} and Palatnikov, {Grigoriy M.} and McDonald, {Thomas J.} and Autenrieth, {Robin L.} and Donnelly, {K. C.} and Anderson, {Todd A.} and Canas, {Jaclyn E.} and Arif Islamzadeh and Bickham, {John W.}",

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Matson, CW, Palatnikov, GM, McDonald, TJ, Autenrieth, RL, Donnelly, KC, Anderson, TA , Canas, JE, Islamzadeh, A & Bickham, JW 2005, 'Patterns of genotoxicity and contaminant exposure: Evidence of genomic instability in the marsh frogs (Rana ridibunda) of Sumgayit, Azerbaijan', Environmental Toxicology and Chemistry, vol. 24, no. 8, pp. 2055-2064. https://doi.org/10.1897/04-250R1.1

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AU - Autenrieth, Robin L.

AU - Donnelly, K. C.

AU - Anderson, Todd A.

AU - Canas, Jaclyn E.

AU - Islamzadeh, Arif

AU - Bickham, John W.

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Patterns of genotoxicity and contaminant exposure: Evidence of genomic instability in the marsh frogs (Rana ridibunda) of Sumgayit, Azerbaijan

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