Patterns of genotoxicity and contaminant exposure: Evidence of genomic instability in the marsh frogs (Rana ridibunda) of Sumgayit, Azerbaijan

Cole W. Matson, Grigoriy M. Palatnikov, Thomas J. McDonald, Robin L. Autenrieth, K. C. Donnelly, Todd A. Anderson, Jaclyn E. Canas, Arif Islamzadeh, John W. Bickham

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The wetlands of Sumgayit in the Azerbaijan Republic contain complex mixtures of contaminants, including polycyclic aromatic hydrocarbons (PAHs), mercury, organochlorine pesticides, and polychlorinated biphenyls. Marsh frogs (Rana ridibunda) were collected from several contaminated wetlands within the city as well as from two reference sites outside the city. Sediment samples revealed heterogeneous patterns of PAH and mercury concentrations throughout Sumgayit, with the highest levels occurring east of the Sumgayit River, within the industrial zone. Flow cytometry and micronucleus assay revealed elevated estimates of genetic damage in frogs from the wetlands east of the Sumgayit River compared to frogs from the reference sites. Flow cytometric data showed a significant correlation with sediment mercury concentrations, whereas population micronucleus frequencies were significantly correlated with high-molecular-weight PAHs.

Original languageEnglish
Pages (from-to)2055-2064
Number of pages10
JournalEnvironmental Toxicology and Chemistry
Volume24
Issue number8
DOIs
StatePublished - Aug 2005

Keywords

  • Azerbaijan
  • Biomarkers
  • Flow cytometry
  • Micronucleus
  • Rana ridibunda

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