Paralemnolins x and y, new antimicrobial sesquiterpenoids from the soft coral paralemnalia thyrsoide

Abdelsamed I. Elshamy, Tarik A. Mohamed, Eman M. Elkady, Ibrahim A. Saleh, Ahmed A. El-Beih, Montaser A. Alhammady, Shinji Ohta, Akemi Umeyama, Paul W. Paré, Mohamed Elamir F. Hegazy

Research output: Contribution to journalArticlepeer-review

Abstract

The organic extracts of the Red Sea soft coral Paralemnalia thyrsoides has led to the identification of two neolemnane-type sesquiterpenoids: paralemnolins X and Y (1, 2). In addition to these newly characterized compounds, ten known metabolites (3–12) were isolated. Previously reported compounds were elucidated by literature comparison of spectroscopic data (1D and 2D NMR as well as MS data). In vitro antimicrobial activity was investigated for compounds (1–12) against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger. Compound 5 showed antimicrobial activity against all assayed microorganisms.

Original languageEnglish
Article number1158
JournalAntibiotics
Volume10
Issue number10
DOIs
StatePublished - Oct 2021

Keywords

  • Antimicrobial
  • Paralemnalia thyrsoide
  • Paralemnolins
  • Sesquiterpenes

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