Palladium(II)-catalyzed direct arylation of enaminones using organotrifluoroborates

Haibo Ge, Micah J. Niphakis, Gunda I. Georg

Research output: Contribution to journalArticle

145 Scopus citations

Abstract

A Pd(II)-catalyzed reaction for the direct arylation of cyclic enaminones is reported. The reactivity of electron-rich, electron-poor, and sterically encumbered organotrifluoroborates was investigated. This reaction represents a unique use for organotrifluoroborates as coupling partners and discloses the utility of enaminones for direct-functionalization reactions. It provides immediate access to arylpiperidine, indolizidine, and quinolizidine scaffolds from the corresponding mono- and bicyclic, unattenuated enaminones.

Original languageEnglish
Pages (from-to)3708-3709
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number12
DOIs
StatePublished - Mar 26 2008

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