Abstract
The direct cyanomethylation of unactivated sp3 C-H bonds of aliphatic amides was achieved via palladium catalysis assisted by a bidentate directing group with good functional group compatibility. This process represents the first example of the direct cross-coupling of sp3 C-H bonds with acetonitrile. Considering the importance of the cyano group in medicinal and synthetic organic chemistry, this reaction will find broad application in chemical research.
Original language | English |
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Pages (from-to) | 2804-2808 |
Number of pages | 5 |
Journal | Chemical Science |
Volume | 7 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2016 |