Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp3)-H bonds with acetonitrile

Yongbing Liu, Ke Yang, Haibo Ge

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The direct cyanomethylation of unactivated sp3 C-H bonds of aliphatic amides was achieved via palladium catalysis assisted by a bidentate directing group with good functional group compatibility. This process represents the first example of the direct cross-coupling of sp3 C-H bonds with acetonitrile. Considering the importance of the cyano group in medicinal and synthetic organic chemistry, this reaction will find broad application in chemical research.

Original languageEnglish
Pages (from-to)2804-2808
Number of pages5
JournalChemical Science
Issue number4
StatePublished - Apr 1 2016


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