Palladium-catalyzed direct asymmetric C-H bond functionalization enabled by the directing group strategy

Ke Yang; Mengjie Song; Hao Liu; Haibo Ge

doi:10.1039/d0sc03052j

Palladium-catalyzed direct asymmetric C-H bond functionalization enabled by the directing group strategy

Ke Yang, Mengjie Song, Hao Liu, Haibo Ge

Chemistry and Biochemistry

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

In the past decade, selective C-C and C-heteroatom bond construction through palladium-catalyzed direct C-H bond functionalization has been extensively studied by employing a variety of directing groups. Within this category, direct asymmetric C(sp2)-H and C(sp3)-H activation for the construction of highly enantiomerically enriched skeletons still progressed at a slow pace. This minireview briefly introduces the major advances in the field for palladium-catalyzed direct asymmetric C-H bond functionalization via the directing group strategy.

Original language	English
Pages (from-to)	12616-12632
Number of pages	17
Journal	Chemical Science
Volume	11
Issue number	47
DOIs	https://doi.org/10.1039/d0sc03052j
State	Published - Dec 21 2020

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title = "Palladium-catalyzed direct asymmetric C-H bond functionalization enabled by the directing group strategy",

abstract = "In the past decade, selective C-C and C-heteroatom bond construction through palladium-catalyzed direct C-H bond functionalization has been extensively studied by employing a variety of directing groups. Within this category, direct asymmetric C(sp2)-H and C(sp3)-H activation for the construction of highly enantiomerically enriched skeletons still progressed at a slow pace. This minireview briefly introduces the major advances in the field for palladium-catalyzed direct asymmetric C-H bond functionalization via the directing group strategy.",

author = "Ke Yang and Mengjie Song and Hao Liu and Haibo Ge",

note = "Funding Information: We gratefully acknowledge the NSF (CHE-2029932), Robert A. Welch Foundation (D-2034-20200401), and Texas Tech University for nancial support. Ke Yang is grateful for the nancial support from the NSFC (No. 21702019) and Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University. Publisher Copyright: {\textcopyright} 2020 The Royal Society of Chemistry.",

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doi = "10.1039/d0sc03052j",

language = "English",

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T1 - Palladium-catalyzed direct asymmetric C-H bond functionalization enabled by the directing group strategy

AU - Yang, Ke

AU - Song, Mengjie

AU - Liu, Hao

AU - Ge, Haibo

N1 - Funding Information: We gratefully acknowledge the NSF (CHE-2029932), Robert A. Welch Foundation (D-2034-20200401), and Texas Tech University for nancial support. Ke Yang is grateful for the nancial support from the NSFC (No. 21702019) and Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University. Publisher Copyright: © 2020 The Royal Society of Chemistry.

PY - 2020/12/21

Y1 - 2020/12/21

N2 - In the past decade, selective C-C and C-heteroatom bond construction through palladium-catalyzed direct C-H bond functionalization has been extensively studied by employing a variety of directing groups. Within this category, direct asymmetric C(sp2)-H and C(sp3)-H activation for the construction of highly enantiomerically enriched skeletons still progressed at a slow pace. This minireview briefly introduces the major advances in the field for palladium-catalyzed direct asymmetric C-H bond functionalization via the directing group strategy.

AB - In the past decade, selective C-C and C-heteroatom bond construction through palladium-catalyzed direct C-H bond functionalization has been extensively studied by employing a variety of directing groups. Within this category, direct asymmetric C(sp2)-H and C(sp3)-H activation for the construction of highly enantiomerically enriched skeletons still progressed at a slow pace. This minireview briefly introduces the major advances in the field for palladium-catalyzed direct asymmetric C-H bond functionalization via the directing group strategy.

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U2 - 10.1039/d0sc03052j

DO - 10.1039/d0sc03052j

M3 - Review article

AN - SCOPUS:85095749092

VL - 11

SP - 12616

EP - 12632

JO - Chemical Science

JF - Chemical Science

SN - 2041-6520

IS - 47

ER -

Palladium-catalyzed direct asymmetric C-H bond functionalization enabled by the directing group strategy

Abstract

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