Palladium-catalyzed direct asymmetric C-H bond functionalization enabled by the directing group strategy

Ke Yang, Mengjie Song, Hao Liu, Haibo Ge

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

In the past decade, selective C-C and C-heteroatom bond construction through palladium-catalyzed direct C-H bond functionalization has been extensively studied by employing a variety of directing groups. Within this category, direct asymmetric C(sp2)-H and C(sp3)-H activation for the construction of highly enantiomerically enriched skeletons still progressed at a slow pace. This minireview briefly introduces the major advances in the field for palladium-catalyzed direct asymmetric C-H bond functionalization via the directing group strategy.

Original languageEnglish
Pages (from-to)12616-12632
Number of pages17
JournalChemical Science
Volume11
Issue number47
DOIs
StatePublished - Dec 21 2020

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