Palladium-catalyzed chemoselective decarboxylative ortho acylation of benzoic acids with α-oxocarboxylic acids

Jinmin Miao, Haibo Ge

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

Palladium-catalyzed chemoselective decarboxylative cross coupling of benzoic acids with α-oxocarboxylic acids was realized via an arene sp 2 C-H functionalization process. This work represents the first example of transition-metal-catalyzed cross-coupling reactions with two acids acting in different roles. The synthetic utility of this method was confirmed by the synthesis of pitofenone, an antispasmodic used in the combined drug Spasmalgon.

Original languageEnglish
Pages (from-to)2930-2933
Number of pages4
JournalOrganic Letters
Volume15
Issue number12
DOIs
StatePublished - Jun 21 2013

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