Palladium-catalyzed C3 acylation of benzofurans and benzothiophenes with aromatic aldehydes by cross-dehydrogenative coupling reactions

Jincan Zhao, Hong Fang, Chen Xie, Jianlin Han, Guigen Li, Yi Pan

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

C-3Pd: A direct C3 acylation of benzofurans and benzothiophenes by sp2 C-H activation catalyzed by palladium acetate is reported. tert-Butyl hydroperoxide (TBHP) is used as the oxidant and aldehydes are used as aroyl sources to give the desired products in excellent yields. This cross-dehydrogenative coupling reaction provides practical access to 3-acylbenzofurans and 3-acylbenzothiophenes.

Original languageEnglish
Pages (from-to)1044-1047
Number of pages4
JournalAsian Journal of Organic Chemistry
Volume2
Issue number12
DOIs
StatePublished - Dec 2013

Keywords

  • Benzofurans
  • Benzothiophenes
  • C-H activation
  • Cross-dehydrogenative coupling
  • Palladium

Fingerprint Dive into the research topics of 'Palladium-catalyzed C3 acylation of benzofurans and benzothiophenes with aromatic aldehydes by cross-dehydrogenative coupling reactions'. Together they form a unique fingerprint.

  • Cite this