Palladium-catalyzed aziridination of alkenes using N,N-dichloro-p-toluenesulfonamide as nitrogen source

Jianlin Han, Yufeng Li, Sanjun Zhi, Yi Pan, Cody Timmons, Guigen Li

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

N,N-Dichloro-p-toluenesulfonamide (TsNCl2) was found to be an efficient nitrogen source for the aziridination of unfunctionalized alkenes using palladium catalysts. Among the palladium salts, palladium acetate was the most effective catalyst for this reaction. A variety of alkenes were reacted at room temperature with TsNCl2 to form the desired aziridines in moderate to good yields. This method can complement our previous protocol which is limited to the use of electron-deficient α,β-unsaturated alkenes.

Original languageEnglish
Pages (from-to)7225-7228
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number40
DOIs
StatePublished - Oct 2 2006

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