Paclitaxel succinate analogs: Anionic and amide introduction as a strategy to impart blood-brain barrier permeability

Brandon J. Turunen, Haibo Ge, Jariat Oyetunji, Kelly E. Desino, Veena Vasandani, Sarah Güthe, Richard H. Himes, Kenneth L. Audus, Anna Seelig, Gunda I. Georg

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

A focused library of TX-67 (C10 hemi-succinate) analogs has been prepared, including C7 regioisomers, esters, amides, and one-carbon homologs. These were prepared to investigate whether the lack of TX-67 interaction with P-glycoprotein (Pgp) is due to the presence of the carboxylic acid moiety and whether this phenomenon was restricted to C10 analogs. Tubulin stabilization ability, cytotoxicity, and Pgp interactions were evaluated. All carboxylic acid analogs and several of the amides had no apparent interactions with Pgp at the concentrations used, whereas the ester variants displayed characteristics of Pgp substrates. Furthermore, it was demonstrated that hydrogen-bonding properties were significant with respect to Pgp interactions. Calculations of log D and cross-sectional areas revealed that these analogs are predicted to partition into the membrane and can compete for Pgp binding sites. The anionic and amide introduction strategy may allow for delivery of paclitaxel into the CNS and may be a potential approach for the delivery of other, structurally complex and lipophilic non-CNS permeable drugs.

Original languageEnglish
Pages (from-to)5971-5974
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number22
DOIs
StatePublished - Nov 15 2008

Keywords

  • Amides
  • Analogues
  • Blood-brain barrier
  • Brain permeability
  • Cytotoxicity
  • P-glycoprotein
  • Paclitaxel
  • Polar surface
  • Succinates
  • TX-67
  • Tubulin assembly
  • log D

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