Oxygenated cembrene diterpenes from sarcophyton convolutum: Cytotoxic sarcoconvolutum a–e

Tarik A. Mohamed, Abdelsamed I. Elshamy, Asmaa M. Abdel-Tawab, Mona M. Abdelmohsen, Shinji Ohta, Paul W. Pare, Mohamed Elamir F. Hegazy

Research output: Contribution to journalArticlepeer-review

Abstract

The soft coral genus Sarcophyton contains the enzymatic machinery to synthesize a multitude of cembrene-type diterpenes. Herein, highly oxygenated cembrenoids, sarcoconvolutum A–E (1–5) were purified and characterized from an ethyl acetate extract of the red sea soft coral, Sarcophyton convolutum. Compounds were assemblies according to spectroscopic methods including FTIR, 1D-and 2D-NMR as well as HRMS. Metabolite cytotoxicity was tested against lung adenocarcinoma, cervical cancer, and oral-cavity carcinoma (A549, HeLa and HSC-2, respectively). The most cytotoxic compound, (4) was observed to be active against cell lines A549 and HSC-2 with IC50 values of 49.70 and 53.17 µM, respectively.

Original languageEnglish
Article number519
JournalMarine Drugs
Volume19
Issue number9
DOIs
StatePublished - Sep 2021

Keywords

  • Cembrenoids
  • Cytotoxicity
  • Sarcoconvolutum A–E
  • Sarcophyton convolutum

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