Oxidative dehydrogenative couplings of pyrazol-5-amines selectively forming azopyrroles

Bo Jiang, Yi Ning, Wei Fan, Shu Jiang Tu, Guigen Li

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


New oxidative dehydrogenative couplings of pyrazol-5-amines for the selective synthesis of azopyrrole derivatives have been described. The former reaction simultaneously installs C-I and N-N bonds through iodination and oxidation, whereas the latter involved a copper-catalyzed oxidative coupling process. The resulting iodo-substituted azopyrroles were employed by treatment with various terminal alkynes through Sonogashira cross-coupling leading to new azo compounds.

Original languageEnglish
Pages (from-to)4018-4024
Number of pages7
JournalJournal of Organic Chemistry
Issue number9
StatePublished - May 2 2014


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