Overexpression of AtPTPA in arabidopsis increases protein phosphatase 2A activity by promoting holoenzyme formation and ABA negatively affects holoenzyme formation

Jian Chen, Xunlu Zhu, Guoxin Shen, Hong Zhang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

AtPTPA is a critical regulator for the holoenzyme assembling of protein phosphatase 2A (PP2A) in Arabidopsis. Characterization of AtPTPA improves our understanding of the function and regulation of PP2A in eukaryotes. Further analysis of AtPTPA-overexpressing plants indicates that AtPTPA increases PP2A activity by promoting PP2A’s AC dimer formation, thereby holoenzyme assembling. Plant hormone abscisic acid (ABA) reduces PP2A enzyme activity by negatively affects PP2A’s AC dimer formation. Therefore, AtPTPA is a positive factor that promotes PP2A holoenzyme assembly, and ABA is a negative factor that prevents PP2A holoenzyme assembly.

Original languageEnglish
Article numbere1052926
JournalPlant Signaling and Behavior
Volume10
Issue number11
DOIs
StatePublished - Dec 2 2015

Keywords

  • Arabidopsis
  • PP2A holoenzyme assembly
  • PP2Ac methylation
  • Protein phosphatase 2A

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