Overexpression of AtPTPA in arabidopsis increases protein phosphatase 2A activity by promoting holoenzyme formation and ABA negatively affects holoenzyme formation

Jian Chen; Xunlu Zhu; Guoxin Shen; Hong Zhang

doi:10.1080/15592324.2015.1052926

Overexpression of AtPTPA in arabidopsis increases protein phosphatase 2A activity by promoting holoenzyme formation and ABA negatively affects holoenzyme formation

Jian Chen, Xunlu Zhu, Guoxin Shen, Hong Zhang

Biological Sciences

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

AtPTPA is a critical regulator for the holoenzyme assembling of protein phosphatase 2A (PP2A) in Arabidopsis. Characterization of AtPTPA improves our understanding of the function and regulation of PP2A in eukaryotes. Further analysis of AtPTPA-overexpressing plants indicates that AtPTPA increases PP2A activity by promoting PP2A’s AC dimer formation, thereby holoenzyme assembling. Plant hormone abscisic acid (ABA) reduces PP2A enzyme activity by negatively affects PP2A’s AC dimer formation. Therefore, AtPTPA is a positive factor that promotes PP2A holoenzyme assembly, and ABA is a negative factor that prevents PP2A holoenzyme assembly.

Original language	English
Article number	e1052926
Journal	Plant Signaling and Behavior
Volume	10
Issue number	11
DOIs	https://doi.org/10.1080/15592324.2015.1052926
State	Published - Dec 2 2015

Keywords

Arabidopsis
PP2A holoenzyme assembly
PP2Ac methylation
Protein phosphatase 2A

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10.1080/15592324.2015.1052926

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title = "Overexpression of AtPTPA in arabidopsis increases protein phosphatase 2A activity by promoting holoenzyme formation and ABA negatively affects holoenzyme formation",

abstract = "AtPTPA is a critical regulator for the holoenzyme assembling of protein phosphatase 2A (PP2A) in Arabidopsis. Characterization of AtPTPA improves our understanding of the function and regulation of PP2A in eukaryotes. Further analysis of AtPTPA-overexpressing plants indicates that AtPTPA increases PP2A activity by promoting PP2A{\textquoteright}s AC dimer formation, thereby holoenzyme assembling. Plant hormone abscisic acid (ABA) reduces PP2A enzyme activity by negatively affects PP2A{\textquoteright}s AC dimer formation. Therefore, AtPTPA is a positive factor that promotes PP2A holoenzyme assembly, and ABA is a negative factor that prevents PP2A holoenzyme assembly.",

keywords = "Arabidopsis, PP2A holoenzyme assembly, PP2Ac methylation, Protein phosphatase 2A",

author = "Jian Chen and Xunlu Zhu and Guoxin Shen and Hong Zhang",

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T1 - Overexpression of AtPTPA in arabidopsis increases protein phosphatase 2A activity by promoting holoenzyme formation and ABA negatively affects holoenzyme formation

AU - Chen, Jian

AU - Zhu, Xunlu

AU - Shen, Guoxin

AU - Zhang, Hong

PY - 2015/12/2

Y1 - 2015/12/2

N2 - AtPTPA is a critical regulator for the holoenzyme assembling of protein phosphatase 2A (PP2A) in Arabidopsis. Characterization of AtPTPA improves our understanding of the function and regulation of PP2A in eukaryotes. Further analysis of AtPTPA-overexpressing plants indicates that AtPTPA increases PP2A activity by promoting PP2A’s AC dimer formation, thereby holoenzyme assembling. Plant hormone abscisic acid (ABA) reduces PP2A enzyme activity by negatively affects PP2A’s AC dimer formation. Therefore, AtPTPA is a positive factor that promotes PP2A holoenzyme assembly, and ABA is a negative factor that prevents PP2A holoenzyme assembly.

AB - AtPTPA is a critical regulator for the holoenzyme assembling of protein phosphatase 2A (PP2A) in Arabidopsis. Characterization of AtPTPA improves our understanding of the function and regulation of PP2A in eukaryotes. Further analysis of AtPTPA-overexpressing plants indicates that AtPTPA increases PP2A activity by promoting PP2A’s AC dimer formation, thereby holoenzyme assembling. Plant hormone abscisic acid (ABA) reduces PP2A enzyme activity by negatively affects PP2A’s AC dimer formation. Therefore, AtPTPA is a positive factor that promotes PP2A holoenzyme assembly, and ABA is a negative factor that prevents PP2A holoenzyme assembly.

KW - Arabidopsis

KW - PP2A holoenzyme assembly

KW - PP2Ac methylation

KW - Protein phosphatase 2A

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JO - Plant Signaling and Behavior

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Overexpression of AtPTPA in arabidopsis increases protein phosphatase 2A activity by promoting holoenzyme formation and ABA negatively affects holoenzyme formation

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