@article{2dfac6696f594fa7ad6b755e9e6e0792,
title = "One-pot synthesis of densely functionalized thiazoles and syn-3-Thioacrylates",
abstract = "A sequential one-pot, two-step reaction has been established for ecient synthesis of densely functionalized thiazoles and syn-3-Thioacrylates. Treatment of cyanoacetamide with isothiocyanates gave rise to 2-cyano-3-mercaptoacrylamides, trapped by but-2-ynedioates through [3+2] cyclization to access functionalized thiazoles. Using propiolates to replace but-2-ynedioates, the reaction resulted in highly substituted syn-3-Thioacrylates. The present green synthesis shows several advantages including operational simplicity and fast reaction rates, which makes it a useful and attractive process of library generation for drug discovery.",
author = "Dang, {Yi Jing} and Sun, {Mu Yan} and Meng, {Xiao Yan} and Zhao, {Fu Jie} and Hao, {Wen Juan} and Bo Jiang and Tu, {Shu Jiang} and Guigen Li",
note = "Funding Information: We are grateful for financial support from the NSFC (No. 21232004, 21272095, 21472071 and 21332005), PAPD of Jiangsu Higher Education Institutions, the Qing Lan Project (12QLG006), Robert A. Welch Foundation (D-1361, USA) and NIH (R33DA031860, USA), the Outstanding Youth Fund of Jiangsu Normal University (YQ2015003), and Natural Science Foundation of Jiangsu Normal University (14XLR005). Publisher Copyright: {\textcopyright} 2016 The Japan Institute of Heterocyclic Chemistry.",
year = "2016",
doi = "10.3987/COM-15-S(T)31",
language = "English",
volume = "93",
pages = "529--544",
journal = "Heterocycles",
issn = "0385-5414",
number = "2",
}